ALPROLIX® offers effective hemostatic control for both major and minor surgeries1
Perioperative dosing with ALPROLIX
Pediatric and adult/adolescent dosing targets for perioperative management
Type of surgery
Target circulating factor IX
(IU/dL or % of normal)
Dosing interval
Minor
(including uncomplicated
dental extraction)
50-80
A single infusion may be sufficient. Repeat as needed after 24-48 hours until bleeding stops and healing is achieved
Major
(with or without anesthesia, includes any surgery where a major body cavity was penetrated and exposed, or a substantial impairment of physical or physiological functions was produced)
60-100
Consider a repeat dose after 6-10 hours and then every 24 hours for the first 3 days.
Due to the long half-life of ALPROLIX, the dose may be reduced, and the frequency of dosing in the postsurgical setting may be extended after Day 3 to every 48 hours or longer until bleeding stops and healing is achieved
- Thirty-five major surgeries were performed in 22 patients during B-LONG and B-YOND1
- An additional 62 minor surgeries were performed in 37 patients during B-LONG, Kids B-LONG, and B-YOND1